Study Definitive Alopecia in cancer patients: epidemiological, clinical and prognostic factors

Study Definitive Alopecia in cancer patients

The Dermatology Service of the Ramón y Cajal Hospital has launched the study “Definitive Alopecia in cancer patients: epidemiological, clinical and prognostic factors”. This is a research project to determine the possible factors that allow predicting that patients will develop definitive alopecia after having received an oncological treatment based on the analysis of the epidemiological and clinical characteristics and the treatments that have received the patients who Have developed this type of alopecia.

Alopecia is a frequent adverse effect of some chemotherapy drugs; however, it is usually reversible and the patient regains full capillary density around 3-6 months after the end of the oncological treatment that produced it; However, in some cases, this alopecia is not completely or partially reversible.

Definitive alopecia is defined as loss of partial or total capillary density that persists 6 months after the end of the cause that caused it. The cause of this alopecia seems to be direct damage on follicular stem cells.

Alopecia has a great impact on the quality of life in the patients affected by this disease, and in many cases patients are anxious about the possibility of losing their hair when starting an oncological treatment; This anxiety sometimes leads patients to reject such treatments.

However, there are no large series published that allow to analyze in detail the profile of patients at risk for this alopecia or the possible predictive factors of it.

This study is performed in cancer patients clinically diagnosed with definitive alopecia.

Description of the study

The study consists of two visits in consultation separated by 6 months, in which the dermatologist will ask the patient a series of questions about his illness, the treatments he has used since he was diagnosed the disease and the response to each one , Will also be made an anamnesis centered on his problem of alopecia and a clinical exploration directed with obtaining iconography making clinical and dermatoscopic photographs of the scalp in order to assess the degree of alopecia and how it evolves in the time elapsed between the two Visits.

In the case of diagnostic doubt, the complementary examinations that are convenient in the case will be carried out, following the usual clinical practice. Finally, the patient will perform a validated quality of life test, to study the impact that this disease causes in daily life. If it is considered opportune the dermatologist can guide a treatment for alopecia, whose answer will be evaluated in the second visit.

Both the research team and the Hospital will not receive any financial compensation for the study.

Purpose of this research study

The main objective is to describe the epidemiological characteristics, personal history, clinical characteristics, prognosis and therapeutics of a wide range of cancer patients with definitive alopecia, as well as to try to define possible predictive factors for the development of this disease.

Benefits of participating in this study

The patient who enters the study can benefit from the knowledge that is obtained from the same therapeutic prognostic level.

Possible risks of participating in this study

There is no risk to health derived from participation in this study.

Participation and withdrawal of the study

Participation in this study is entirely voluntary. The patient may discontinue his participation in this study at any time, without affecting the medical care he receives.

Contact details for more information

The study physician and / or team members will be available to answer any questions that may arise about the study. For more information, please contact Dr. Ángela Hermosa Gelbard by calling 913368247/913368582 or by sending an email to:

Clash Royale: how you can respond to the Baby Dragon

Baby Dragon Clash Royale

In Clash Royale there are a great deal of various soldiers that we could utilize in every fight, however this additionally suggests that our challengers have the very same deal. Among one of the most irritating is the Baby dragon, which has sufficient assault as well as functions as a storage tank, so today you instruct a couple of ideas to neutralize efficiently the infant dragon:

Usage array soldiers

Infant dragon have splash damages, or that will certainly introduce assaults that will certainly hurt all the soldiers or structures that are within its distance of assault, nonetheless little, that is. The excellent part of all this is that will certainly strike range, and also we have to do the very same for finishing it without issues, so we have to utilize any kind of army that assault from afar.

Do not place soldiers near to the tower

As we claimed, the infant dragon has location damages, so it is a really poor concept to soldiers near the Tower, given that although they are arqueras that assault at range, the dragon will certainly create damages to whatever in its objective. Learn any tips how to get Clash Royale free gems here

Wait on the Baby Dragon to technique to the tower

If we wish to conserve the issue of getting damages in the tower as well as shedding soldiers, the most effective method is to wait till the infant dragon mark as unbiased the Tower prior to the soldiers of response. Some spirits with spear or a display, and also we eliminate the Dragon in the center.

Make use of a Hog Rider or structure’s support

The Hog Rider, although it is not a protection army, is the very best to neutralize the Baby dragon due to the fact that it will certainly make you to transform totally to aim to eliminate him, while our Tower assaults him continuous. On the other hand, a structure’s support is additionally incredibly reliable, which will certainly additionally end up being to the remainder of the soldiers when the dragon drops.

Currently I have actually instructed you how you can respond to the Royal prince, how you can respond to the wizard, ways to respond to the Golem, ways to respond to the spell of ice and also the best ways to respond to the x-ballesta, however remember to undergo the remainder of our overviews of fundamental ideas, progressed to obtain tips, mistakes which we need to stay clear of, when to strike the Tower of the King, ways to establish a deck as well as method the benefit of potion along with our overviews for the level up quickly, obtain much gold and also make runs of success, obtain legendary letters, obtain epic cards obtain supermagicos breasts and also secure free treasures to be unstoppable in the video game of Supercell.

Less Common types of Breast Cancer


Inflammatory breast cancer: In this type of cancer cancer cells infiltrate lymphatic vessels and skin. The breast becomes reddish and hot and can become larger, firm, tender or itchy. In its early stages, inflammatory breast cancer is often confused with mastitis or infection in the breast and treated with antibiotics. If the symptoms are caused by cancer, they will not be relieved. It accounts for approximately 1 to 3% of all breast cancers.

Paget’s disease of the nipple or Paget’s disease mammary: is a rare type of cancer that affects the skin of the nipple and the areola that present eczema, crusts, scales and, sometimes, areas of bleeding or suppuration. Paget’s disease is almost always associated with ductal carcinoma in situ or infiltrating ductal carcinoma. The prognosis and treatment of the disease depend on the type of tumor to which it is associated. It represents approximately 1% of all breast cancers.

Phyloid tumor or filoid cistosarcoma: This type of tumor in the breast is rare and is formed in the breast tissue, unlike the carcinomas that form in the ducts or lobules. They tend to grow rapidly, but they rarely spread outside the breast. Most phyloid tumors are benign (noncancerous), some are malignant (cancerous) and some ambiguous. They account for less than 1% of all breast tumors.

Marrow carcinoma of the breast: This type of cancer is a rare subtype of invasive ductal carcinoma. It does not grow rapidly and usually does not extend outside the breast to the lymph nodes. It most often affects women who have a BRCA1 gene mutation.

Colloid carcinoma or mucinous carcinoma of the breast: a rare form of invasive ductal carcinoma. This type of cancer is formed from cancerous cells that produce mucus in the breast ducts.

Tubular carcinoma of the breast: a rare subtype of invasive ductal carcinoma. In this type of cancer, it is generally low grade and slow growing. The low-grade concept in a tumor refers to the fact that cancer cells look similar to normal healthy cells and tend to grow slowly.

8 Ball Pool Free Download and install Complete Newest Variation

8 Ball Pool

8 Ball Pool is one of the most preferred PC Video game in this globe at this time.It is a fascinating video game. that call is 8 Ball Pool Free Most recent variation. This video game was created by Midas Interactive. 8 Ball Pool was launched on 10 Aug 2008. It is really Special Game.It is simple to use.You understand that Daily2soft website are give the most effective and also Most recent Variation of Hint Club with functioning link.You could quickly Download and install Pool Hints from my website absolutely free of cast.Thanks For seeing my blog site.

The 3D graphics typically aren’t fancy yet suffice in order to help you take pleasure in video game play, allowing you removal the video camera as well as zoom quickly. 8 Ball Pool is easy to use as well as the audio impacts are precise, much like in a genuine pool hall.

Ideal As well as Most recent Qualities of 8 Ball Pool Video game:

  • Extremely Cool photo Impact
  • Mainly individuals are playing this video game
  • HD And also 3D Graphics
  • Various as well as lots of sorts of sticks
  • Web content of Tournaments offered in this variation right here
  • Snooker signs is extremely basic PC Video game
  • It is really easy to use
  • Pool Cues is really renowned Video game
  • 8-ball Pool video game
  • Easy to experienced problem
  • Conserve as well as fill video game
  • You secure free video game tips and also aid From Daily2soft
  • Excellent quality make
  • Download this cost-free complete variation billiard video game currently!

Exactly what’s New ??

New attribute offered! The leading table currently obtains harder and also extra enjoyable with the enhancement of the “Padding Shot on 8 Ball” regulation. Can you still be the very best as well as handle the leading ability?
Insect solutions and also efficiency renovations. You can see more information about 8 Ball Pool tips and guides by visiting

System Needs:

  • Running System: Windows View, Windows 7, Windows 8, Windows 8.1 or greater.
  • Ram: 512 MEGABYTES.
  • Hard drive Room: 500 MEGABYTES.
  • Video Card: 3D equipment sped up with 16-bit shade screen.
  • Audio Card: Yes.